Endocrine Abstracts

Ocular function is fundamental for environmental adaptation and survival capacity. Growth factors are thought to be necessary to reach a mature eyeball and consequent adequate vision. However, the consequences of the deficiency of circulating growth hormone (GH) and its effector insulin-like growth factor I (IGF-I) on the physical aspects of the human eye are still debated. A model of untreated isolated GH deficiency (IGHD) may clarify this issue. The aim of this study was to ...

Maternal exposures during pregnancy to endocrine disrupting chemicals increase daughter’s breast cancer risk in humans and animal models. We have previously found that these exposures also pre-program offspring’s mammary tumors to exhibit increased resistance to antiestrogen therapy, and that treatment with valproic acid (HDAC inhibitor) and hydralazine (DNMT inhibitor) prevented antiestrogen resistance. Here we investigated if maternal exposure to ethinyl estradiol ...

Maternal exposures during pregnancy to endocrine disrupting chemicals increase daughter’s breast cancer risk in humans and animal models. We have previously found that these exposures also pre-program offspring’s mammary tumors to exhibit increased resistance to antiestrogen therapy, and that treatment with valproic acid (HDAC inhibitor) and hydralazine (DNMT inhibitor) prevented antiestrogen resistance. Here we investigated if maternal exposure to ethinyl estradiol ...

Background: Basal tumor markers are valuable in preoperative evaluation of medullary thyroid carcinoma (Calcitonin and CEA), but are insensitive and nonspecific for papilary thyroid cancer (thyroglobulin). Even if their utility is questionable or not recomended in the evaluation of thyroid nodules, in some cases refered to endocrinology department they are available and can be misleading. We present two cases of thyroid nodules with very high preoperative tumor markers.<p ...

Pheochromocytoma is a rare tumor made up of chromaffin cells from the adrenal medulla that secrete catecholamines. It can occur at any age, with a peak incidence between the fourth and fifth decade of life, and only 10% of cases occur in children. The majority of cases are sporadic and approximately 10% are malignant. The existence of familial syndrome, multiple or extra adrenal tumors is more common at younger ages. The clinic is very variable, and hypertension (HTA) is the m...

Background: The development of a new syringe for lanreotide Autogel, in conjunction with patients, caregivers and HCPs, identified and integrated several upgrades to the previous design that could improve patient care.Aims: To better understand which attributes are pertinent to users, and how user preferences can be optimally assessed, we conducted a systematic literature review of relevant studies of pre-filled devices.Methods: Pu...

Introduction: MODYs are being identified more frequently but the rarity of some types still precludes in-dept knowledge of their natural course of disease. One of this rare forms is MODY 5, the result of a mutation on the hepatocyte nuclear factor 1 beta (HNF-1B) gene that associates with genitourinary and pancreatic malformations/dysfunction.Case report: A 24-year-old female was referred to the Endocrinology clinic due to hyperglycaemia identified on pr...

A female patient was first referred to the Endocrinology department due to primary amenorrhea at age 37. She mentioned trans-sphenoidal surgery at age 15 due to a craniopharyngioma and the indication to be supplemented with hydrocortisone (HC) and DDAVP, that she adhered to until age 20, when she abandoned all appointments. Apart from that, she mentioned normal pubertal development and said she was generally healthy. She denied any episodes compatible with Addisonian crises. F...

Introduction: Primary lymphoma of the thyroid (PTL) is a rare cause of malignancy, accounting for 5% of thyroid malignancies, with an annual estimated incidence of 2 per 1 million. Women are more commonly affected than men (2–8:1). Patients typically present in the sixth or seventh decade of life. Most thyroid lymphomas are non-Hodgkin’s lymphomas (NHLs) of B-cell origin. Patients with Hashimoto’s thyroiditis are at greater risk for developing PTL. Treatment and...

Hypothalamic GH releasing hormone (GHRH) has hypnotic actions by increasing slow wave sleep (SWS) (non-rapid eye movement sleep, non-REM), which account for about 75% of sleep. Conversely, GH may stimulate the rapid eye movement sleep (REM). Patients with GH deficiency (GHD) often exhibit sleep problems leading to daytime fatigue and reduced quality of life (QoL). We have described a cohort of patients with isolated GHD (IGHD) due to GHRH resistance caused by a homozygous null...